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NONMEM® is a nonlinear mixed effects modelling tool used in population pharmacokinetic/pharmacodynamic analysis. NONMEM stands for NONlinear Mixed Effects Modeling. NONMEM is a computer program that is implemented in Fortran90/95. It solves pharmaceutical statistical problems in which within subject and between subjects variability is taken into account when fitting a pharmacokinetic and/or pharmacodynamic (PK/PD) model to data. The appropriate statistical analysis using the appropriate model helps pharmaceutical companies determine appropriate dosing strategies for their products, and increases their understanding of drug mechanisms and interactions.